Professor Sim’s current research has arisen from investigation of the molecular basis of different individuals’ responses to environmental chemicals using druginduced immunotoxicity and industrial bladder cancer as model systems. In both of these multi-factorial disorders, polymorphism in metabolism of an environmental chemical by arylamine N-acetyltransferases (NAT) is a key factor. NATs are a unique family of enzymes found in many organisms and form the central theme of her research.
Measurement of dopamine release ‘on-line’ from brain slices using fast scan cyclic voltammetry. Real time monitoring of release of a protein from the brain. Electrophysiological recording from brain slices in vitro and substantia nigra in vivo in both physiological and pathological conditions. Study of mechanisms underlying regeneration and development of the pathway lost in Parkinson’s and Alzheimer's disease, using organotypic co-cultures Organotypic tissue culture.