Dr Daniel C Anthony
How mediators of the inflammatory response contribute to the outcome of spinal or brain injuries. How events in others organs, such as the liver, contribute to the outcome of brain injury or disease. In particular (with the Neuroimaging group), we are studying the mechanisms that give rise to the reactivation of a Multiple sclerosis-like lesions by a systemic inflammatory response. How brain injury contributes to the outcome of disease elsewhere in the body with a focus on how hepatic NFkB activity contributes to the acute phase response after CNS injury (with Dr Mann, Southampton). How inflammation affects brain serotonin function and the relevance to depression (with Dr Sharp and the Neuroimaging group).
Dr Daniel Anthony
Dr Daniel Anthony joined the Department in 2004 from Southampton (1998-2004) and runs the Experimental Neuropathology Laboratory. The focus of the work of our laboratory is research to identify how inflammation contributes to the outcome of acute and chronic brain injury or infection. There is now considerable evidence to support the idea that inflammation contributes, in a deleterious manner, not only to the archetypal inflammatory disease of the brain, multiple sclerosis, but also to acute neurological diseases, such as stroke and head trauma, and to chronic neurodegenerative diseases, such as Alzheimer's disease, prion disease, and HIV-related dementia.
The laboratory is recognised both nationally and internationally and has close ties with Dr Sibson’s Experimental Neuroimaging Group at Radiation, Oncology and Biology (ROB), Oxford. Dr Anthony was a Glaxo graduate student in the Department of Surgery, University College London where he worked with Professor Paul Boulos examining the role of metalloproteinases in Inflammatory Bowel Disease. Following the completion of his PhD in 1994, Dr Anthony joined Professor Hugh Perry, then in Oxford, on a British Biotech Fellowship investigating metalloproteinase expression in the CNS. It was during this period that he became interested in the leukocyte-mediated mechanisms of neurodegeneration. Dr Anthony also held a position as retained lecturer at Trinity College Oxford in this period (1994-1998).
- Anti-IL-17A Treatment Reduces Clinical Score and VCAM-1 Expression Detected by in Vivo Magnetic Resonance Imaging in CR-EAE ABH Mice.
- Mardiguian, S, Serres, S, Ladds, E, Campbell, SJ, Wilainam, P, McFadyen, C, McAteer, M, Choudhury, RP, Smith, P, Saunders, F, Watt, G, Sibson, NR, and Anthony, DC
Am J Pathol.
- Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis.
- Serres, S, Bristow, C, de Pablos, RM, Merkler, D, Soto, MS, Sibson, NR, and Anthony, DC
J Cereb Blood Flow Metab, 33(5):744-53.
- Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia.
- Couch, Y, Anthony, DC, Dolgov, O, Revischin, A, Festoff, B, Santos, AI, Steinbusch, HW, and Strekalova, T
Brain Behav Immun, 29:136-46.
- Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy.
- Wolfensohn, S, Hawkins, P, Lilley, E, Anthony, D, Chambers, C, Lane, S, Lawton, M, Robinson, S, Voipio, H, and Woodhall, G
J Pharmacol Toxicol Methods, 67(1):9-15.
- Reducing suffering in experimental autoimmune encephalomyelitis (EAE).
- Wolfensohn, S, Hawkins, P, Lilley, E, Anthony, D, Chambers, C, Lane, S, Lawton, M, Voipio, H, and Woodhall, G
J Pharmacol Toxicol Methods, 67(3):169-76.
- Special issue commentary: the changing face of inflammation in the brain.
- Anthony, DC and Pitossi, FJ
Mol Cell Neurosci, 53:1-5.
- Systemic inflammation alters central 5-HT function as determined by pharmacological MRI.
- Couch, Y, Martin, CJ, Howarth, C, Raley, J, Khrapitchev, AA, Stratford, M, Sharp, T, Sibson, NR, and Anthony, DC
- The differential effects of chronic imipramine or citalopram administration on physiological and behavioral outcomes in naive mice.
- Strekalova, T, Anthony, DC, Dolgov, O, Anokhin, K, Kubatiev, A, Steinbusch, HMW, and Schroeter, C
Behav Brain Res, 245:101-6.