Professor Kim Dora

BHF Senior Basic Science Research Fellow
Vascular Pharmacology Research Group
Vascular endothelial cell function in health and disease.

Research summary

Dr Kim Dora

Dr Dora's research focuses on cell-cell communication in resistance arteries and arterioles. Predominantly focussing on signalling pathways within the endothelium, she uses sophisticated and novel techniques to monitor rapid changes in intracellular Ca2+ and how they link to the activation of dilator pathways. Her work has shown that  gap junctions between endothelial and smooth muscle cells enable the spread of current and Ca2+ signals between the cell types, and as a result, control arterial diameter. How these signals are generated and modulated is of ongoing interest.

Spontaneous vasomotion, followed by dilatation to 1 µM ACh in an isolated, triple cannulated and pressurized arteriole. Feed arteriole ~1000 µm long.

Dr Dora’s research is currently focussed on 5 main research areas 1) intra- and inter-cellular Ca2+ imaging in isolated pressurized small arteries and arterioles, 2) endothelium-dependent control of arterial diameter, 3) electrical events leading to conducted dilatation, 4) lumen-specific actions of agonists and 5) how these processes are affected by endothelial dysfunction.

Spontaneous and agonist-mediated endothelial cell Ca2+ events in an isolated pressurized arteriole. An agonist acting at endothelial cell muscarinic receptors was added t=6 s. Movie 10x real time, frame width 250 µm.

Biography

Dr Dora obtained a BSc (Biochemistry) at the Australian National University and a PhD with Professor Michael Clark in Biochemistry from the University of Tasmania. She was then awarded a CJ Martin Overseas Research Fellowship (from the NH&MRC Australia) to work with Dr Brian Duling in the Department of Physiology and Biological Physics at the University of Virginia, USA. In 1997 she moved to the UK to the Department of Pharmacology at the University of Bristol to work with Professor Chris Garland. She became a Lecturer at the University of Bath in 2000, where she became Senior Lecturer and then Reader in Vascular Pharmacology. In 2008 she was awarded a BHF Senior Basic Science Research Fellowship and moved to Pharmacology in Oxford in October.

Dr Dora is on the Council of the British Pharmacological Society, and is an Editor for the British Journal of Pharmacology (2003-2009). She is the Endothelium SIG coordinator for the BPS.

Collaborators

  • Prof Chris Garland, Professor of Vascular Pharmacology, University of Oxford
  • Dr Pooneh Bagher, Postdoctoral Research Fellow, University of Oxford
  • Dr Esteban Sepulveda Kattan, Postdoctoral Researcher, University of Oxford
  • Dr Chris Stanley, Postdoctoral Researcher, University of Oxford
  • Harrison Davis, DPhil Student, University of Oxford
  • Chloe Lim, DPhil Student, University of Oxford
  • Ray Mitchell, Imaging Data Analyzer, University of Oxford
  • Dr Timea Beleznai, Postdoctoral Fellow, University of Oxford
  • Dr Rosalia Rodriguez-Rodriguez
  • Dr Polina Yarova

Publications