Professor Kim Dora
Dr Kim Dora
Dr Dora's research focuses on cell-cell communication in resistance arteries and arterioles. Predominantly focussing on signalling pathways within the endothelium, she uses sophisticated and novel techniques to monitor rapid changes in intracellular Ca2+ and how they link to the activation of dilator pathways. Her work has shown that gap junctions between endothelial and smooth muscle cells enable the spread of current and Ca2+ signals between the cell types, and as a result, control arterial diameter. How these signals are generated and modulated is of ongoing interest.
Spontaneous vasomotion, followed by dilatation to 1 µM ACh in an isolated, triple cannulated and pressurized arteriole. Feed arteriole ~1000 µm long.
Dr Dora’s research is currently focussed on 5 main research areas 1) intra- and inter-cellular Ca2+ imaging in isolated pressurized small arteries and arterioles, 2) endothelium-dependent control of arterial diameter, 3) electrical events leading to conducted dilatation, 4) lumen-specific actions of agonists and 5) how these processes are affected by endothelial dysfunction.
Spontaneous and agonist-mediated endothelial cell Ca2+ events in an isolated pressurized arteriole. An agonist acting at endothelial cell muscarinic receptors was added t=6 s. Movie 10x real time, frame width 250 µm.
Dr Dora obtained a BSc (Biochemistry) at the Australian National University and a PhD with Professor Michael Clark in Biochemistry from the University of Tasmania. She was then awarded a CJ Martin Overseas Research Fellowship (from the NH&MRC Australia) to work with Dr Brian Duling in the Department of Physiology and Biological Physics at the University of Virginia, USA. In 1997 she moved to the UK to the Department of Pharmacology at the University of Bristol to work with Professor Chris Garland. She became a Lecturer at the University of Bath in 2000, where she became Senior Lecturer and then Reader in Vascular Pharmacology. In 2008 she was awarded a BHF Senior Basic Science Research Fellowship and moved to Pharmacology in Oxford in October.
Dr Dora is on the Council of the British Pharmacological Society, and is an Editor for the British Journal of Pharmacology (2003-2009). She is the Endothelium SIG coordinator for the BPS.
- Prof Chris Garland, Professor of Vascular Pharmacology, University of Oxford
- Dr Pooneh Bagher, Postdoctoral Research Fellow, University of Oxford
- Dr Esteban Sepulveda Kattan, Postdoctoral Researcher, University of Oxford
- Dr Chris Stanley, Postdoctoral Researcher, University of Oxford
- Harrison Davis, DPhil Student, University of Oxford
- Chloe Lim, DPhil Student, University of Oxford
- Ray Mitchell, Imaging Data Analyzer, University of Oxford
- Dr Timea Beleznai, Postdoctoral Fellow, University of Oxford
- Dr Rosalia Rodriguez-Rodriguez
- Dr Polina Yarova
- Dora, KA and Garland, CJ (2013) Linking hyperpolarization to endothelial cell calcium events in arterioles.
- Dora, KA and Hill, MA (2013) Measurement of changes in endothelial and smooth muscle Ca(2)(+) in pressurized arteries.
- Bagher, P, Beleznai, T, Kansui, Y, Mitchell, R, Garland, CJ, and Dora, KA (2012) Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.
- Beleznai, T, Takano, H, Hamill, C, Yarova, P, Douglas, G, Channon, K, and Dora, K (2011) Enhanced K(+)-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE(-/-) mice.
- Beleznai, TZ, Yarova, PL, Yuill, KH, and Dora, KA (2011) Smooth muscle Ca(2+) -activated and voltage-gated K+ channels modulate conducted dilation in rat isolated small mesenteric arteries.
- Clifford, PS, Ella, SR, Stupica, AJ, Nourian, Z, Li, M, Martinez-Lemus, LA, Dora, KA, Yang, Y, Davis, MJ, Pohl, U, Meininger, GA, and Hill, MA (2011) Spatial distribution and mechanical function of elastin in resistance arteries: a role in bearing longitudinal stress.
- Garland, CJ, Yarova, PL, Jimenez-Altayo, F, and Dora, KA (2011) Vascular hyperpolarization to beta-adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries.
- Garland, CJ, Hiley, CR, and Dora, KA (2011) EDHF: spreading the influence of the endothelium.
- Ella, SR, Yang, Y, Clifford, PS, Gulia, J, Dora, KA, Meininger, GA, Davis, MJ, and Hill, MA (2010) Development of an image-based system for measurement of membrane potential, intracellular Ca(2+) and contraction in arteriolar smooth muscle cells.
- Dora, KA (2010) Coordination of vasomotor responses by the endothelium.
- Yuill, KH, McNeish, AJ, Kansui, Y, Garland, CJ, and Dora, KA (2010) Nitric oxide suppresses cerebral vasomotion by sGC-independent effects on ryanodine receptors and voltage-gated calcium channels.
- Dora, KA, Gallagher, NT, McNeish, A, and Garland, CJ (2008) Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries.
- Kansui, Y, Garland, CJ, and Dora, KA (2008) Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.
- Garland, CJ and Dora, KA (2008) Evidence against C-type natriuretic peptide as an arterial 'EDHF'.