Research summary

• Physiology and pharmacology of midbrain monoamine systems
• Neuropharmacology of antidepressants
• Neural mechanisms of mood and anxiety

Trevor Sharp graduated in Biochemistry at the University of Birmingham in 1979. He established his interest inneuropharmacology of CNS transmitters in the Department of Physiology and Pharmacology at the University of Nottingham where he obtained his PhD in 1983.

He spent the next three years in the Department of Pharmacology at the Karolinska Institute, Stockholm with Urban Ungerstedt as a SERC and Karolinska Institute Overseas Fellow.

In 1986 he joined the MRC Unit of Clinical Pharmacology in Oxford, and was appointed to the MRC External Scientific Staff in 1993. Following a further six years in the Department of Clinical Pharmacology, he joined the Department of Pharmacology at the start of the new millennium. Throughout his time in Oxford, Trevor Sharp’s research has focused on the pharmacology and physiology of monoamine transmitters, particularly in relation to the treatment and cause of psychiatric disorder. He holds visiting Professorships with the Universities of Maastricht and Hokkaido, and is currently a member of the executive committee of the Serotonin Club.

Collaborators

• Florence Serres, Postdoctoral Researcher
• Judith Schweimer, Postdoctoral Researcher
• Ivi Antoniadou, DPhil Student
• Katharina Stumpenhorst, DPhil Student
• Julia Brouard, DPhil Student
• Charlotte Cooper, DPhil Student
• Sebastian Schilling, Master's Student
• Dominic Ballard, • Dissertation Student
• Poppy Walker, • Dissertation Student
• Angela Sheard, Dissertation Student

2013

Systemic inflammation alters central 5-HT function as determined by pharmacological MRI.

Couch, Y, Martin, CJ, Howarth, C, Raley, J, Khrapitchev, AA, Stratford, M, Sharp, T, Sibson, NR, and Anthony, DC
Neuroimage, 75C:185-194.