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The conjugate addition of an enantiopure lithium amide to a ζ-hydroxy-α,β-unsaturated ester followed by a one-pot ring-closure/N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts), and (R,R)-1-(hydroxymethyl)octahydroindolizine (the bicyclic fragment of stellettamides A-C). © 2011 Elsevier Ltd. All rights reserved.

Original publication

DOI

10.1016/j.tet.2011.09.038

Type

Journal article

Journal

Tetrahedron

Publication Date

23/12/2011

Volume

67

Pages

9975 - 9992