Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A large variety of GABAergic interneurons control information processing in the hippocampal circuits governing the formation of neuronal representations. Whether distinct hippocampal interneuron types contribute differentially to information processing during behavior is not known. We employed a new technique for recording and labeling interneurons and pyramidal cells in drug-free, freely moving rats. Recorded parvalbumin-expressing basket interneurons innervated somata and proximal pyramidal cell dendrites, whereas nitric oxide synthase- and neuropeptide Y-expressing ivy cells provided synaptic and extrasynaptic dendritic modulation. Basket and ivy cells showed distinct spike-timing dynamics, firing at different rates and times during theta and ripple oscillations. Basket, but not ivy, cells changed their firing rates during movement, sleep and quiet wakefulness, suggesting that basket cells coordinate cell assemblies in a behavioral state-contingent manner, whereas persistently firing ivy cells might control network excitability and homeostasis. Different interneuron types provide GABA to specific subcellular domains at defined times and rates, thereby differentially controlling network activity during behavior.

Original publication

DOI

10.1038/nn.3176

Type

Journal article

Journal

Nat Neurosci

Publication Date

09/2012

Volume

15

Pages

1265 - 1271

Keywords

Analysis of Variance, Animals, Axons, Behavior, Animal, Dendrites, Electric Stimulation, Electrodes, Implanted, Electroencephalography, Electrophysiological Phenomena, Evoked Potentials, Hippocampus, Immunohistochemistry, Interneurons, Microscopy, Electron, Nerve Net, Nerve Tissue Proteins, Parvalbumins, Pyramidal Cells, Rats, Rats, Sprague-Dawley