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Cyclic 8-bromo-inosine-5'-diphosphate ribose (8-Br-N1-cIDPR) was cleanly degraded at acidic pH by N9 ribosyl scission and subsequent pyrophosphate cleavage to give 8-bromo-N1-ribosyl hypoxanthine 5'-monophosphate (8-Br-N1-IMP), a novel class of mononucleotide, as the sole product.

Original publication

DOI

10.1039/b517916e

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

14/03/2006

Pages

1127 - 1129

Keywords

Cyclic ADP-Ribose, Hypoxanthine, Lactones, Models, Molecular, Molecular Conformation, Phosphates, Stereoisomerism