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Using a chemoenzymatic approach we synthesized a number of structurally-modified analogues of the novel Ca2+-releasing cyclic nucleotide cADPR. This produced novel agonists, antagonists and enzyme inhibitors to investigate this new signalling pathway, and also the first membrane permeable antagonist.

Original publication

DOI

10.1080/10426509908546295

Type

Journal article

Journal

Phosphorus, Sulfur and Silicon and Related Elements

Publication Date

01/01/1999

Volume

144-146

Pages

517 - 520