Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

PURPOSE: Data relating to the role that Human immunodeficiency virus (HIV) contributes towards seizures in HIV-infected children is limited. The management of seizures in this group is complex due to potential interactions between antiseizure medication and antiretroviral therapies. This study explores the seizure semiology and course of a population of affected children based on questions raised from a previous epidemiological study. METHODS: A retrospective case-control study of all patients presenting to an HIV neurology clinic between 2008-2015 was conducted. A multinomial logistic regression model was used to identify risk factors for seizure occurrence in HIV-infected children, as well as factors associated with seizure control. RESULTS: Of 227 HIV-infected children (median 82 months, interquartile range 41-109), 52 (23%) reported a past or present history of seizures. Prior bacterial meningitis (p =  0.03, OR 12.5, 95% CI 1.2-136.1), cerebrovascular accident (CVA, p =  0. 005, OR 8.1, 95% CI 1.9-34.9) and or tuberculous meningitis (TBM, p =  0.0004) was associated with an increased risk of seizures in HIV-infected children. Generalised tonic-clonic seizures were the predominant seizure type (64%) with the majority caused by an infectious aetiology (62%). Thirty-two (62%) of these patients had epilepsy in-line with the latest diagnostic criteria. HIV-infected children with epilepsy who were treated with efavirenz were more likely to have poor seizure control (OR 23.1 95% CI 3.4-159.6, p =  0.0001). CONCLUSIONS: This study provides new data highlighting the complex clinical presentation and management challenges of HIV-infected children with seizures.

Original publication

DOI

10.1016/j.seizure.2019.01.023

Type

Journal article

Journal

Seizure

Publication Date

02/2019

Volume

65

Pages

159 - 165

Keywords

Anticonvulsants, Antiretrovirals, Comorbidities, Epilepsy, HIV, Paediatrics, Seizures, Adolescent, Anticonvulsants, Antiviral Agents, Case-Control Studies, Child, Child, Preschool, Female, HIV Infections, Humans, Infant, Male, Neuroimaging, Risk Factors, Seizures, South Africa, Statistics, Nonparametric