Xi Ye
BSc(Hons), PhD
Visiting Researcher
I am interested in the mechanisms regulating arterial contractility and dilation. Vascular tone plays an important role in the regulation of blood flow and blood pressure in normal physiology and in a number of diseases including hypertension, diabetes and ischaemic diseases. My current research focuses on how calcium signalling in small arteries can control blood vessel diameter.
Recently, I have described how alternative splicing of VEGF-A can regulate blood vessel formation and affect the progression of infantile haemangioma, the most common neoplasm of infancy. I am now investigating how VEGF-A, which is elevated in a number of pathological conditions, can contribute to endothelial dysfunction and vascular diseases
Recent publications
-
VEGF-A inhibits agonist-mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells.
Journal article
Ye X. et al, (2018), J Physiol, 596, 3553 - 3566
-
Physiological role of vascular endothelial growth factors as homeostatic regulators
Journal article
Bates DO. et al, (2018), Comprehensive Physiology
-
VEGF-A inhibits agonist-mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells
Journal article
Ye X. et al, (2018), Journal of Physiology
-
Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice.
Journal article
Lemmey HAL. et al, (2018), Vascul Pharmacol, 103-105, 29 - 35
-
The kindlin-2 double act.
Journal article
Ye X. and Dora KA., (2017), J Physiol, 595