The Ellender group recently demonstrated that distinct embryonic progenitor pools in the lateral ganglionic eminence (LGE), which generate the spiny projection neurons of the striatum, convey key features to their progeny. Of these features it was the synaptic integration within large-scale neuronal circuits that was most profoundly impacted by progenitor pool of origin. For example, the striatal spiny projection neurons derived from so-called apical intermediate progenitors expressing the gene tubulin-1 were mainly innervated by the medial prefrontal cortex – a brain region that has been implicated in a plethora of neurological and psychiatric disorders. This finding allows for further exploration and study of this important pathway in the future.
https://www.sciencedirect.com/science/article/pii/S2211124721003570
New Ellender group paper explores link between neurons and progenitor pools
16 June 2021