A Department of Pharmacology start-up company has received approval from the US Food and Drug Administration (FDA) for a new treatment for the rare lysosomal storage disorder Niemann-Pick Disease Type C (NPC) in both adults and children.
As part of the Medical Sciences Division's series on industry collaboration, Pharmacology's Associate Professor Sri Vasudevan shares the important of networking at conferences and listening to a range of views as vital building blocks that can lead to effective commercial partnerships.
Professor Angela Russell, who holds a joint appiontment with the Departments of Pharmacology and Chemistry, is one of four scientists from the University of Oxford who have won prizes from the Royal Society of Chemistry in recognition of brilliance in research and innovation. The awards are among the oldest and most prestigious research prizes in the world, having recognised excellence in the chemical sciences for more than 150 years.
Researchers in the Lanyon-Hogg group in the Department of Pharmacology, in collaboration with the Ineos Oxford Institute for antimicrobial research (IOI), have developed a new small molecule that can suppress the evolution of antibiotic resistance in bacteria and make resistant bacteria more susceptible to antibiotics. The findings have been published in the journal Chemical Science.
A new paper by the Akerman Group is published in the journal Cell Reports this week and reveals how fine scale synaptic connectivity in the adult brain is shaped by events during embryonic development.
A collaborative chemical biology study from the Potter Group, with the Gonzalez Group at CSIC Madrid, deepens understanding of an enzyme acting upon a crucial cellular messenger.
Pharmacology staff and students contributed to a special afternoon of events last week to engage 200-300 students and families on the theme of the brain organised by their school \u2018Rumble Museum\u2019. A team of ten members of our department led by Dr Lizzie Burns developed five zones of activities to engage students with different aspects of neuroscience: memory, focus, build-a-brain, illusion and microscopy.
A successful Phase 3 clinical trial of N-acetyl-leucine (NALL) in the lysosomal storage disorder Niemann-Pick disease type C has been published this month in the New England Journal of Medicine.
A new study jointly published by Professors David Smith and Helga Refsum confirms that chronic exposure to air pollution in the elderly increases the risk of developing dementia a few years later.
A new paper by the Akerman Group is published in the journal Neuron this week, and resolves a fundamental question in the field of neuroscience, by investigating how synaptic inhibition operates under undisturbed conditions. This new study demonstrates that GABA signaling in the brain is dynamic and adapts to control cortical functions depending on the state of the brain.
The latest David Smith Lecture in Anatomical Neuropharmacology was held in the Department on Wednesday 14 June 2023. Professor Annette Dolphin from the Department of Neuroscience, Physiology and Pharmacology at University College London presented a highly engaging lecture entitled \"Drugs and trafficking: lessons from voltage-gated calcium channels\".
A collaborative study just published from the Potter group in the Department of Pharmacology, in collaboration with the Butler Group at Loughborough University, reveals the development of a small molecule Europium-based probe that could deepen our understanding of a crucial cellular messenger and potentially facilitate the development of new therapeutic drugs.
Congratulations to the group of Professor Nigel Emptage who have been awarded an MRC-AMED grant, worth \u00a31m, in conjuction with the University of Tokyo and the RIKEN Center for Brain Science
This image of a blood clot composed of erythrocytes trapped by long fibrous chains of fibrin was judged the winner of the image competition at the BHF CRE 2022 Symposiium, held in December. In this image we can see false coloured erythrocytes (classic biconcave appearance around 5-10 \u00b5m in diameter) wrapped by fibrin network.
A group of researchers and students led by Dr Tim Viney visited Didcot Girls School to run a \u2018hands on\u2019 event about the brain at the school\u2019s Science Club.
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