Dr Timm will use the award to procure an Oroboros FluoRespirometer, for high resolution respirometry in mitochondria, cells and permeabilised tissue fibres. The Oroboros can also simultaneously measure ROS production, mitochondrial membrane potential and calcium concentration. The technology will be used to underpin in vivo metabolic imaging results from chemotherapy-induced cardiotoxicity models with ex vivo comprehensive analysis of mitochondrial function.
Having the Oroboros FluoRespirometer in house will allow Dr Timm to start Oxford-wide and external collaborations. Seven PIs across Oxford supported Dr Timm's AMS application, including PIs involved in neurometabolism, immunometabolism and diabetes.