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Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN
Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN

Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms mediating this are unknown. The Vasudevan lab in Pharmacology in collaboration with the Foster and Jagannath group at NDCN and other international collaborators show that adenosine receptor antagonist shifts circadian rhythms and enhance the effects of light, providing a key molecular link between sleep pressure and circadian rhythms. Paper link: https://www.nature.com/articles/s41467-021-22179-z#Sec34

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