Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN
Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN

Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms mediating this are unknown. The Vasudevan lab in Pharmacology in collaboration with the Foster and Jagannath group at NDCN and other international collaborators show that adenosine receptor antagonist shifts circadian rhythms and enhance the effects of light, providing a key molecular link between sleep pressure and circadian rhythms. Paper link: https://www.nature.com/articles/s41467-021-22179-z#Sec34

Similar stories

New insight into the pharmacology of a therapeutic ion channel target

A new paper, published by the Tammaro lab in the Proceedings of the National Academy of Sciences (PNAS), shines new light on potential sites for pharmacological intervention within TMEM16A channels.

J Harold Burn (1892-1981)

A world-leading pharmacologist who built up the Department

New BHF study offers potential of new clinical options for cardiac treatment

A new study, led by Professor Kim Dora in association with Professor Raimondo Ascione at the University of Bristol, has shown abnormalities in the tiny blood vessels of human hearts which cannot be detected by current heart scans. Poor myogenic (automatic) tone, where blood flow in these vessels is abnormal, is thought to develop independent of disease in the larger arteries, which can be treated using stents or bypass surgeries.

Professor Fran Platt elected to The Royal Society

We were delighted to learn from the announcement today, 6 May 2021, that Professor Fran Platt has been elected a Fellow of The Royal Society. She is one of the 52 distinguished scientists whose election was announced, and one of the two biologists out of six Oxford academics so-honoured this year. https://royalsociety.org/news/2021/05/new-fellows-announcement-2021/