Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN
Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN

Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms mediating this are unknown. The Vasudevan lab in Pharmacology in collaboration with the Foster and Jagannath group at NDCN and other international collaborators show that adenosine receptor antagonist shifts circadian rhythms and enhance the effects of light, providing a key molecular link between sleep pressure and circadian rhythms. Paper link: https://www.nature.com/articles/s41467-021-22179-z#Sec34