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Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN
Model delineating signalling pathways downstream of both adenosine (changing as a function of sleep) and light signalling within the SCN

Sleep pressure and circadian rhythms influence one another. However, the regulatory mechanisms mediating this are unknown. The Vasudevan lab in Pharmacology in collaboration with the Foster and Jagannath group at NDCN and other international collaborators show that adenosine receptor antagonist shifts circadian rhythms and enhance the effects of light, providing a key molecular link between sleep pressure and circadian rhythms. Paper link: https://www.nature.com/articles/s41467-021-22179-z#Sec34

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Cardiac arrhythmias pose a serious global health challenge. The commonest sustained arrhythmia atrial fibrillation (AF) affects 1–2% of the worldwide population. Antiarrhythmic drugs (AADs) remain central to their pharmacotherapeutic management. As a solution, Professors Ming Lei, Derek Terrar (both Pharmacology), Christopher Huang (University of Cambridge), and Lin Wu (Beijing University Hospital) developed and proposed the 2018 Oxford modernized antiarrhythmic drug (AAD) classification (Circulation, 2018;138:1879–1896).