Carbohydrate-derived amino-alcohol ligands for asymmetric alkynylation of aldehydes.
Emmerson DPG., Hems WP., Davis BG.
[reaction: see text] Conformationally restricted amino alcohols based on carbohydrate scaffolds provide flexible and fine-tuneable libraries that greatly expand the range of ligands available in the Zn(OTf)(2)-mediated addition of alkynes to aldehydes, in some cases with very high stereoselectivities.