Development of chronic secondary epileptic foci following intrahippocampal injection of tetanus toxin in the rat.
Jefferys JG., Empson RM.
It is known that injecting a minute dose of tetanus toxin into rat hippocampus leads to a chronic epileptic syndrome. Here we describe the development of secondary, 'mirror' epileptic foci in the hippocampus contralateral to a single injection of the toxin (12 mouse LD50). This was detected in slices in vitro prepared 6 to 56 days after injection, both as evoked after-discharges and as spontaneous synchronous bursts that were mainly restricted to subregions CA3b and c.