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The first total chemical synthesis of nicotinamide adenine dinucleotide phosphate (beta-NADP, 2) as a single isomer was achieved. This was subsequently converted into the important second messenger nicotinic acid adenine dinucleotide phosphate (p-NAADP) 1 and the identity of this material confirmed by biological evaluation. This flexible synthetic route offers new opportunities for the generation of NAADP 1 analogues that cannot be generated directly from NADP 2 or mainly enzymatic methods.

Type

Journal article

Journal

Nucleosides Nucleotides Nucleic Acids

Publication Date

2005

Volume

24

Pages

513 - 518

Keywords

Animals, Aplysia, Calcium, Calcium Signaling, Chemistry, Pharmaceutical, Magnetic Resonance Spectroscopy, Models, Chemical, NADP, Second Messenger Systems, Temperature