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LC3-lipidation is activated by lysosomal damage by mechanisms that are unknown and divergent from canonical autophagy. In this study, Nakamura et al, show that lysosomal damage induced by lysosomotropic agents or oxalate in renal proximal tubule cells causes lipidated LC3 to insert into the lysosomal membrane to activate TRPML1 channels and release Ca2+ from lysosomes. This leads to TFEB dephosphorylation and translocation into the nucleus which results in clearance of damaged lysosomes and their contents which may reduce the deleterious effects of crystal nephropathy.

Original publication

DOI

10.1016/j.ceca.2020.102328

Type

Journal article

Journal

Cell Calcium

Publication Date

01/2021

Volume

93

Keywords

Calcium, Crystal nephropathy, LC3, TFEB, TRPML1, mTORC1