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The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.

Original publication

DOI

10.1016/j.bmcl.2010.12.099

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

15/02/2011

Volume

21

Pages

1185 - 1190

Keywords

Amino Alcohols, Antitubercular Agents, Arylamine N-Acetyltransferase, Binding Sites, Catalytic Domain, Computer Simulation, Mycobacterium, Structure-Activity Relationship