A stereochemical investigation of the cyclisation of D-glucose-6[(R)- 16O,17O18O]-phosphate and adenosine- 5′[(R)-16O,17O,18O]phosphate
Jarvest RL., Lowe G., Potter BVL.
D-Glucose-6[(R)-16O 17O,18O]phosphate and adenosine-5′[(R)-16O,17O,18O]phosphate were synthesised and converted (by treatment with diphenyl phosphorochloridate, followed by potassium t-butoxide) into the cyclic 4,6-phosphate and 3′5′-phosphate diesters respectively with retention of configuration at phosphorus, the absolute configuration of D-glucose-6[16O, 17O,18O]-phosphate and adenosine-5′[ 16O,17O,18O]phosphate of unknown chirality at phosphorus can now be determined by 31P n m r spectroscopy.