Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Chronic social defeat stress, a depression model in rats, reduced struggling in the forced swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled less. Social defeat reduced brain regional energy metabolism, and this effect was also more pronounced in rats with high sucrose intake. A number of changes in gene expression were identified after social defeat stress, most notably the down-regulation of Gsk3b and Map1b. The majority of differences were between stress-susceptible and resilient rats. Conclusively, correlates of inter-individual differences in stress resilience can be identified both at gene expression and oxidative metabolism levels.

Original publication




Journal article


Eur Neuropsychopharmacol

Publication Date





92 - 107


Adrenal Glands, Animals, Apomorphine, Behavior, Animal, Body Weight, Brain, Depression, Dopamine Agonists, Energy Metabolism, Gene Expression, Gene Expression Profiling, Microarray Analysis, Rats, Rats, Wistar, Resilience, Psychological, Stress, Psychological, Sucrose, Sweetening Agents, Swimming