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Chronic social defeat stress, a depression model in rats, reduced struggling in the forced swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled less. Social defeat reduced brain regional energy metabolism, and this effect was also more pronounced in rats with high sucrose intake. A number of changes in gene expression were identified after social defeat stress, most notably the down-regulation of Gsk3b and Map1b. The majority of differences were between stress-susceptible and resilient rats. Conclusively, correlates of inter-individual differences in stress resilience can be identified both at gene expression and oxidative metabolism levels.

Original publication

DOI

10.1016/j.euroneuro.2010.06.015

Type

Journal article

Journal

Eur Neuropsychopharmacol

Publication Date

01/2011

Volume

21

Pages

92 - 107

Keywords

Adrenal Glands, Animals, Apomorphine, Behavior, Animal, Body Weight, Brain, Depression, Dopamine Agonists, Energy Metabolism, Gene Expression, Gene Expression Profiling, Microarray Analysis, Rats, Rats, Wistar, Resilience, Psychological, Stress, Psychological, Sucrose, Sweetening Agents, Swimming