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The sperm activates the egg to begin developing into an embryo by triggering a wave of intracellular calcium release, which sweeps across the egg like a forest fire. The identity of the signaling molecules that mediate this fundamental event has remained a mystery until recently. Now, new information emerging from the genome projects has made it possible to isolate and characterize the proteins responsible.


Journal article


Biologist (London)

Publication Date





5 - 10


Animals, Calcium Signaling, Female, Fertilization, Fertilization in Vitro, Humans, Male, Ovum, Parthenogenesis, Sperm-Ovum Interactions, Spermatozoa