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Sea urchin eggs have been an indispensable model system for studying egg activation and ionic signalling for at least a century. Instrumental in the discovery of two Ca(2+)-mobilizing second messengers, cyclic ADP-ribose and NAADP, the sea urchin has revolutionized cell biology for all phyla. This review attempts to summarize what we currently know about egg acidic vesicles in the context of Ca(2+) signalling. The dynamics of Ca(2+) storage, Ca(2+) mobilization, proton fluxes and two-pore channels will be discussed.

Original publication




Journal article


Cell Calcium

Publication Date





147 - 156


Acids, Animals, Antiporters, Calcium, Calcium Channels, Calcium Signaling, Calcium-Transporting ATPases, Cation Transport Proteins, Cyclic ADP-Ribose, Cytoplasmic Vesicles, Fertilization, Hydrogen-Ion Concentration, NADP, Ovum, Sea Urchins