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A series of novel resorcin-[4]arenes with extended pi systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

Type

Journal article

Journal

Chemistry

Publication Date

17/08/2001

Volume

7

Pages

3474 - 3481

Keywords

Carrier Proteins, Indicators and Reagents, Lipid Bilayers, Membrane Potentials, Molecular Conformation, Molecular Structure, Potassium, Potassium Channels, Resorcinols