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Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur with a proton pump. This effect can be accounted for by changes to the GABA A receptor reversal potential and demonstrates an important difference between silencing strategies. © 2012 Nature America, Inc. All rights reserved.

Original publication

DOI

10.1038/nn.3143

Type

Journal article

Journal

Nature Neuroscience

Publication Date

01/08/2012

Volume

15

Pages

1102 - 1104