Solid phase peptide templated glycosidic bond formation
Tennant-Eyles RJ., Davis BG., Fairbanks AJ.
Glycosylation reactions performed between a glycosyl donor and acceptor covalently linked to a peptide template both in the solution and solid phase give similar yields and product distributions. The adoption of a solid phase approach opens the way for the synthesis of libraries of peptide templates in an attempt to screen for particular peptide sequences that effect complete regio-and stereochemical control during glycosidic bond formation, whilst the use of second generation donors allows the possibility of an iterative approach. © 2003 Elsevier Science Ltd. All rights reserved.