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The synthesis and conformations of 3-O-methylDMJ, 3-O-(α-D-glucopyranosyl)-DMJ (Glcα1,3DMJ), and 3-O-(α-D-mannopyranosyl)-DMJ (Manα1,3DMJ) are described. Manα1,3DMJ and Glcα1,3DMJ are shown to be very powerful inhibitors of an endomannosidase. The potential use of these compounds in both probing the pathways of N-linked glycoprotein processing and in the chemotherapy of some viral diseases is discussed. © 1993.

Original publication

DOI

10.1016/S0957-4166(00)82250-8

Type

Journal article

Journal

Tetrahedron: Asymmetry

Publication Date

01/01/1993

Volume

4

Pages

2011 - 2024