To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism.
Chem Commun (Camb)
12605 - 12608
Binding Sites, Catalytic Domain, Diphosphates, Inositol Phosphates, Molecular Dynamics Simulation, Phosphotransferases (Phosphate Group Acceptor)