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Ebolavirus, a deadly hemorrhagic fever virus, was thought to enter cells through endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an alternate model was recently proposed in which ebolavirus enters through a later NPC1-negative endosome that contains two-pore Ca(2+) channel 2 (TPC2), a newly identified ebolavirus entry factor. Here, using live cell imaging, we obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 and TPC2.

Original publication




Journal article


J Virol

Publication Date





605 - 610


Animals, Calcium Channels, Carrier Proteins, Cell Line, Chlorocebus aethiops, Ebolavirus, Endosomes, Host-Pathogen Interactions, Humans, Intracellular Signaling Peptides and Proteins, Membrane Glycoproteins, Microscopy, Models, Biological, Viral Envelope Proteins, Virus Internalization