Functionalized main-group organometallics for organic synthesis
Knochel P., Hupe E., Dohle W., Lindsay DM., Bonnet V., Quéguiner G., Boudier A., Kopp F., Demay S., Seidel N., Calaza MI., Vu VA., Sapountzis I., Bunlaksananusorn T.
Highly functionalized Grignard-reagents can be easily obtained by an iodine-magnesim exchange reaction and further reacted with various electrophiles. Via a B-Zn exchange reaction, a formal Michael addition with umpolung of the reactivity can be achieved. Chiral phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement and used successfully in asymmetric synthesis.