Cyclic adenosine 5′-diphosphate ribose-mediated cellular signalling: New insights using synthetic ligands
Potter BVL.
Using a chemoenzymatic approach we synthesized a number of structurally-modified analogues of the novel Ca2+-releasing cyclic nucleotide cADPR. This produced novel agonists, antagonists and enzyme inhibitors to investigate this new signalling pathway, and also the first membrane permeable antagonist.