Synthesis of C5-substituted AE-bicyclic analogues of lycoctonine, inuline and methyllycaconitine
Grangier G., Trigg WJ., Lewis T., Rowan MG., Potter BVL., Blagbrough IS.
We have prepared C5-substituted AE-bicyclic analogues of norditerpenoid alkaloids lycoctonine, inuline and methyllycaconitine via an acetylide anion addition strategy. Using two acetylide anions, we have regioselectively linked two cyclic ketones to acetylene.