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D-Myo-inositol(1,4,5)trisphosphorothioate, a synthetic analogue of inositol(1,4,5)trisphosphate was shown to bind with a relatively high affinity to specific sites on rat cerebellar membranes labelled with [3H]inositol(1,4,5)trisphosphate. Use of this binding assay has also established that unlike the trisphosphate, the trisphosphorothioate is completely resistant to a specific 5-phosphatase prepared from human erythrocytes. The ability of this novel analogue to release intracellular Ca2+ has already been reported and it offers considerable potential in the investigation of phosphoinositide-linked receptors.

Type

Journal article

Journal

Eur J Pharmacol

Publication Date

11/10/1988

Volume

155

Pages

181 - 183

Keywords

Animals, Binding Sites, Cerebellum, Erythrocyte Membrane, Humans, Inositol, Inositol 1,4,5-Trisphosphate, Organothiophosphorus Compounds, Phosphoric Monoester Hydrolases, Rats, Stereoisomerism