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The initial water-soluble product of receptor-stimulate polyphosphoinositide hydrolysis, D-myo-inositol 1,4,5-trisphosphate is now accepted as the second messenger that stimulates release of Ca2+ from intracellular pools. We report here the first examples of Ca2+ release by a novel phosphatase-resistant inositol trisphosphate analogue, DL-myo-inositol 1,4,5-trisphosphorothioate, in Swiss 3T3 cells and Xenopus oocytes. L-myo-inositol 1,4,5-trisphosphate was inactive in the latter system.


Journal article


Biochem Biophys Res Commun

Publication Date





626 - 632


Animals, Calcium, Cell Membrane Permeability, Cells, Cultured, Female, Inositol, Inositol 1,4,5-Trisphosphate, Kinetics, Mice, Oocytes, Organothiophosphorus Compounds, Xenopus laevis