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The manipulation and modulation of biomolecules has the potential to herald new modes of Biology and Medicine through chemical "editing". Key to the success of such processes will be the selectivities, reactivities and efficiencies that may be brought to bear in bond-formation and bond-cleavage in a benign manner. In this Perspective, we use select examples, primarily from our own research, to examine the current opportunities, limitations and the particular potential of metal-mediated processes as exemplars of possible alternative catalytic modes and manifolds to those already found in nature.

Original publication

DOI

10.1021/jacs.8b13187

Type

Journal article

Journal

J Am Chem Soc

Publication Date

22/05/2019

Volume

141

Pages

8005 - 8013

Keywords

Alkynes, Azides, Catalysis, Copper, Palladium, Proteins, Ruthenium