This review presents advances in assays for human C-reactive protein (CRP), the most important biomarker of infection and inflammation for a plethora of diseases and pathophysiological conditions. Routine assays in clinical settings are based on analyzers, enzyme-linked immunosorbent assays and lateral flow assays. However, assays encompassing novel sensing schemes, improved chemistry, signal enhancement, lab-on-a-chip, microfluidics and smartphone detection, have emerged in recent years. The incorporation of immune-transducing chips or sensing interfaces with nanomaterials enables multiplexing analysis of CRP with co-existing biomarkers. However, there are still considerable challenges in the development of rapid diagnostics for both pentameric and monomeric CRP forms.
10.1016/j.biotechadv.2015.12.010
Journal article
2016-01-01T00:00:00+00:00
34
272 - 290
18
Assays, Bioanalytical advances, Biosensors, C-reactive protein, Diagnostics, C-Reactive Protein, Chemistry Techniques, Analytical, Humans