Ca2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevations within neurons, play a pivotal role in determining the downstream consequences of neural signaling on synaptic function. Here, we review the role of three major intracellular stores: the endoplasmic reticulum, mitochondria, and acidic Ca2+ stores, such as lysosomes, in neuronal Ca2+ signaling and plasticity. We provide a comprehensive account of how Ca2+ release from these stores regulates short- and long-term plasticity at the pre- and postsynaptic terminals of central synapses.
Journal article
2019-06-01T00:00:00+00:00
25
208 - 226
18
Ca signaling, Ca stores, LTD, LTP, acidic stores, endoplasmic reticulum, hippocampus, lysosomes, mitochondria, synaptic plasticity, Animals, Calcium Signaling, Dendritic Spines, Endoplasmic Reticulum, Humans, Lysosomes, Mitochondria, Neuronal Plasticity, Neurons, Presynaptic Terminals, Synapses