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Publications

Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol.

Shen Y-C. et al, (2015), Br J Cancer, 113, 1158 - 1167

Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors.

Dohle W. et al, (2014), ChemMedChem, 9, 1783 - 1793

Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones.

Leese MP. et al, (2014), ChemMedChem, 9, 798 - 812

Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines.

Dohle W. et al, (2014), ChemMedChem, 9, 350 - 370

Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors.

Leese MP. et al, (2014), ChemMedChem, 9, 85 - 1

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors.

Leese MP. et al, (2012), ACS Med Chem Lett, 3, 5 - 9

Structure-activity relationships of C-17-substituted estratriene-3-O-sulfamates as anticancer agents.

Jourdan F. et al, (2011), J Med Chem, 54, 4863 - 4879

Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.

Jourdan F. et al, (2010), J Med Chem, 53, 2942 - 2951

A protecting group free synthesis of (+/-)-neostenine via the [5 + 2] photocycloaddition of maleimides.

Lainchbury MD. et al, (2008), J Org Chem, 73, 6497 - 6505

Copper-catalysed meso-bislactone ring opening using Grignard and mixed triorganozinc reagents

Borthwick S. et al, (2006), Tetrahedron Letters, 47, 7205 - 7208

A practical flow reactor for continuous organic photochemistry.

Hook BDA. et al, (2005), J Org Chem, 70, 7558 - 7564

Mild synthesis of polyfunctional benzimidazoles and indoles by the reduction of functionalized nitroarenes with phenylmagnesium chloride.

Dohle W. et al, (2003), Chemistry, 9, 5323 - 5331

Highly functionalized organomagnesium reagents prepared through halogen-metal exchange.

Knochel P. et al, (2003), Angew Chem Int Ed Engl, 42, 4302 - 4320

Expeditious functionalization of quinolines in positions 2 and 8 via polyfunctional aryl- and heteroarylmagnesium intermediates

Staubitz A. et al, (2003), Synthesis, 233 - 242

Synthesis of polyfunctional indoles and related heterocycles mediated by cesium and potassium bases

Koradin C. et al, (2003), Tetrahedron, 59, 1571 - 1587

Preparation of polyfunctional heterocycles using highly functionalized aminated arylmagnesium reagents as versatile scaffolds.

Lindsay DM. et al, (2002), Org Lett, 4, 1819 - 1822

Preparation and reactions of functionalized arylmagnesium reagents

Jensen AE. et al, (2002), Synthesis, 565 - 569

Functionalized main-group organometallics for organic synthesis

Knochel P. et al, (2002), Pure and Applied Chemistry, 74, 11 - 17

Stereoselective preparation of highly functionalized (Z)-3-magnesiated enoates by an iodine-magnesium exchange reaction.

Sapountzis I. et al, (2001), Chem Commun (Camb), 2068 - 2069

Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides.

Dohle W. et al, (2001), Org Lett, 3, 2871 - 2873

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