Our group studies the principles underlying synaptic circuit formation and plasticity. These processes are fundamental to normal brain function, and are implicated in disorders such as epilepsy, schizophrenia and dementia.
Burton Group | Cardiac Dynamics and Pacemaking Research
We investigate sub-cellular anatomy, especially spatial localisation of organelles, and the role of lysosome mediated calcium signalling in normo- and patho-physiology. Some of the techniques employed in our research include confocal microscopy, electron microscopy, MRI and optogenetics and high-speed optical mapping.
Churchill Group | Chemical Tools and Drugs Discovery
We identify and develop small molecules, as either chemical tools to explore basic biology or as drugs to treat disease. We pursue mechanisms controlling calcium signalling and treatments for psychological disorders such as bipolar.
Davis Group | Chemistry of Carbohydrates and Protein
Our research comes under the broad heading of the chemistry of Carbohydrates and Proteins. The reactions and manipulation of sugars and proteins have fascinated organic chemists for over a century and this work is culminating today in a host of new drugs for treating diseases.
Dora Group | Vascular Pharmacology Research
We use electrophysiological and live cell imaging techniques to investigate the fundamental mechanisms controlling the diameter of small arteries and arterioles in health and disease.
Emptage Group | Synaptic Pharmacology
We are interested in synaptic transmission. We wish to understand the way in which synapses behave when functioning normally but also how they change during memory formation or when struck by diseases such as Schizophrenia or Alzheimer’s.
Garland Group | Vascular Pharmacology Research
We use electrophysiological and live cell imaging techniques to investigate the fundamental mechanisms controlling the diameter of small arteries and arterioles in health and disease. These blood vessels regulate tissue blood flow and pressure.
Lanyon-Hogg Group | Medicinal Chemistry & Chemical Biology
Our group uses synthetic chemistry and biochemistry to develop small-molecule therapeutics and generate new insights into fundamental biology. We are interested in using tool molecules and interdisciplinary methodology to identify and validate new drug targets.
Minichiello Group | Cellular and Molecular Neuroscience
We work to find molecular mechanisms that control the activity of nerve cells involved in cognitive processes such as learning and memory, motor behaviour and metabolism.
Parrington Group | Molecular Mechanisms of Cell Signalling
The group’s principal research interest is in using molecular approaches to study how calcium signalling governs key physiological events.
Platt Laboratory | Lysosomal and Sphingolipid Disorders
Our interests are in lysosome biology and how diseases result from lysosomal dysfunction. Our research spans basic cell biology, disease mechanism and therapy. We have successfully developed drugs that are in clinical use.
Potter group | Medicinal, Biological Chemistry & Drug Discovery
We design, synthesise and evaluate biologically active molecules and work at the interfaces of Chemistry with Biology and Medicine. Our synthetic tools probe cell signalling and in Medicinal Chemistry our drugs have reached numerous clinical trials, with clinical benefit for cancer patients.
Sharp Group | Neuropsychopharmacology Research
Our work focuses on understanding the organisation and function of certain neural pathways in the brain that are linked to psychiatric disorder. We are using this knowledge to help identify drugs to improve the treatment of psychiatric disorder.
Sitsapesan Group | Intracellular Ion Channels and Ca²⁺ Release
The release of Ca2+ from intracellular stores is of fundamental importance in cell biology, initiating and regulating a wide variety of cellular functions including muscle contraction, fertilisation, cell division and neurotransmitter release. The focus of our laboratory is the study of intracellularly located ion-channels, particularly in regard to cardiac physiology and disease.
Smith Group | Oxford Project to Investigate Memory and Ageing (OPTIMA) and B Vitamin Research Group
The Group investigates the role of micronutrients, especially B vitamins, in relation to functioning of the brain, in particular in prevention of Alzheimer’s dementia, and in the causation of obesity.
Co-ordinated neuronal activity is intrinsically linked with behaviour and malfunction of neuronal coordination results in psychiatric and neurological disorders. Timing is crucial for neuronal integration including events lasting from milliseconds up to several seconds. Much of the neuronal activity is rhythmic in the brain, as rhythmicity facilitates local and global interactions and enables the representation of temporal sequences.
Tammaro Group | Molecular and Systems Pharmacology of Vascular Ion Channels
Our research aims are two-fold: i) to determine the molecular mechanisms that underlie the function of vascular ion channels, and ii) to identify new ion channel targets and specific drug compounds with the goal of modulating blood vessel function for therapeutic benefit.