Research groups
Alexandria Colaco
Postdoctoral Research Assistant in Lysosomal Storage Diseases
Recent publications
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Mechanistic convergence and shared therapeutic targets in Niemann-Pick disease type C and Tangier disease.
Journal article
Colaco A. et al, (2019), J Inherit Metab Dis
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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress.
Journal article
Höglinger D. et al, (2019), Nat Commun, 10
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Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
Journal article
Moreau D. et al, (2019), EMBO Rep
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AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease.
Journal article
Hughes MP. et al, (2018), Hum Mol Genet, 27, 3079 - 3098
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FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
Journal article
Newton J. et al, (2017), FASEB J, 31, 1719 - 1730