- Wellcome Trust Doctoral Programme in Neuroscience
My research focuses on understanding the pathologic mechanisms underlying epilepsy in order to identify novel curative strategies. At the moment, approximately 1 in 100 people in the UK suffer from epilepsy and a significant number of these patients do not respond to medication.
At one level, epilepsy can be considered as a loss in the balance of synaptic excitation and inhibition in networks of the brain. I am therefore investigating ways to restore this balance, by selectively controlling the activity of specific neuronal populations in a manner that mitigates the initiation and spread of epileptic events. I adopt a targeted approach by combining genetic, optical, viral and pharmacological techniques.
This could strongly impact the way we understand epilepsy as a neurological disease and the manner in which we intervene for the management of epileptic patients.
Chemicogenetic recruitment of specific interneurons suppresses seizure activity
Călin A. et al, (2018)
Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity.
Cǎlin A. et al, (2018), Front Cell Neurosci, 12
Burst-Suppression Ratio on Electrocorticography Depends on Interelectrode Distance.
Moldovan M. et al, (2016), J Clin Neurophysiol, 33, 127 - 132
Fronto-parietal connectivity changes following noxious stimulation during anesthesia.
Pavel B. et al, (2014), J Med Life, 7, 387 - 390
Intraoperative somatosensory evoked potential monitoring decreases EEG burst suppression ratio during deep general anesthesia.
Călin A. et al, (2014), J Clin Neurophysiol, 31, 133 - 137