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Alexandru Calin

DPhil Student

  • Wellcome Trust Doctoral Programme in Neuroscience

My research focuses on understanding the pathologic mechanisms underlying epilepsy in order to identify novel curative strategies. At the moment, approximately 1 in 100 people in the UK suffer from epilepsy and a significant number of these patients do not respond to medication.

At one level, epilepsy can be considered as a loss in the balance of synaptic excitation and inhibition in networks of the brain. I am therefore investigating ways to restore this balance, by selectively controlling the activity of specific neuronal populations in a manner that mitigates the initiation and spread of epileptic events. I adopt a targeted approach by combining genetic, optical, viral and pharmacological techniques.

This could strongly impact the way we understand epilepsy as a neurological disease and the manner in which we intervene for the management of epileptic patients.


Recent publications

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