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Anthony Morgan

BSc (Hons), PhD

Senior Scientist

My research focuses on how cells communicate with one another and the underlying molecular signalling pathways. In particular, how the levels of the intracellular messenger, Ca2+, are controlled by extracellular stimuli in both time and space.

Ca2+ signalling is implicated in myriad cellular events, from fast processes such as neurotransmission to slow processes such as gene expression. When Ca2+ signalling goes wrong, disease ensues. Moreover, Ca2+ signalling pathways can be subverted by infectious agents to their own ends. Therefore, drugs that affect Ca2+ signals may therefore correct diseases or reduce infection.

My current work examines the regulation of Ca2+ release from intracellular Ca2+-storing organelles – mainly endo-lysosomes and the endoplasmic reticulum (ER) – via the second messengers NAADP and IP3. I focus on the bidirectional cross-talk between these two organelles using a combination of molecular biology and single-cell fluorescence microscopy.

Recent publications

More publications