Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Research groups

Brooke Prakash

DPhil Student


Brooke’s research focuses on understanding the mechanisms underlying lithium’s therapeutic action as a mood stabiliser for bipolar disorder. Sleep and biological 24-hour (circadian) rhythm disruptions are well documented in bipolar patients. Lithium normalises these rhythms by increasing their amplitude, period and slow wave sleep, yet the mechanisms underlying its period lengthening and slow wave sleep enhancement remain a mystery. Brooke utilises in vitro and in vivo models to examine these mechanisms. She is also interested in exploring the mechanisms by which lithium contributes to weight gain in certain patient populations.