A new probe illuminates endo-lysosomal Ca2+ measurements: A role for vesicular IP3 receptors?

Morgan AJ.

In this issue, Calvo et al. (https://doi.org/10.1083/jcb.202410094) report a new bioluminescent Ca2+ probe (ELGA) targeted to acidic endo-lysosomes (ELs) to permit selective and dynamic recording of endo-lysosomal Ca2+ uptake and release. Ca2+ was not only released by canonical EL channels but, surprisingly, by IP3 receptors.

DOI

10.1083/jcb.202511020

Type

Journal article

Publication Date

2025-12-01T00:00:00+00:00

Volume

224

Keywords

Inositol 1,4,5-Trisphosphate Receptors, Calcium, Lysosomes, Endosomes, Humans, Calcium Signaling, Animals

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