I am interested in how maternal nutrition during pregnancy and breastfeeding affects offspring neurobiology and behaviour. We have shown that F0 prebiotic feeding in mice during this period has anxiolytic- and antidepressant-like effects in the F1 generation, and alters NMDA receptor gene expression in the prefrontal cortex and hippocampus. By investigating changes in the gut microbiota and associated metabolites, I aim to uncover some of the biological mechanisms that underpin gut-brain axis communication, and by extension how nutrition during pregnancy shapes the CNS immune environment, and behaviour.
IFN-λ Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis.
Sebina I. et al, (2022), J Immunol
Modifying the maternal microbiota alters the gut-brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams.
Radford-Smith DE. et al, (2022), Proc Natl Acad Sci U S A, 119
A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.
Radford-Smith DE. et al, (2022), Liver Int
Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism.
Radford-Smith DE. et al, (2022), PLoS One, 17
SERUM NUCLEAR MAGNETIC RESONANCE METABOLOMIC SIGNATURE CAN DISCRIMINATE IMMUNOGLOBULIN G4-RELATED SCLEROSING CHOLANGITIS AND PRIMARY SCLEROSING CHOLANGITIS
Selvaraj E. et al, (2021), GUT, 70, A2 - A3