Research groups
Colleges
Daniel Radford-Smith
DPhil Student
I am interested in how maternal nutrition during pregnancy and breastfeeding affects offspring neurobiology and behaviour. We have shown that F0 prebiotic feeding in mice during this period has anxiolytic- and antidepressant-like effects in the F1 generation, and alters NMDA receptor gene expression in the prefrontal cortex and hippocampus. By investigating changes in the gut microbiota and associated metabolites, I aim to uncover some of the biological mechanisms that underpin gut-brain axis communication, and by extension how nutrition during pregnancy shapes the CNS immune environment, and behaviour.
Recent publications
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IFN-λ Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis.
Journal article
Sebina I. et al, (2022), J Immunol
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Modifying the maternal microbiota alters the gut-brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams.
Journal article
Radford-Smith DE. et al, (2022), Proc Natl Acad Sci U S A, 119
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A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.
Journal article
Radford-Smith DE. et al, (2022), Liver Int
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Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism.
Journal article
Radford-Smith DE. et al, (2022), PLoS One, 17
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SERUM NUCLEAR MAGNETIC RESONANCE METABOLOMIC SIGNATURE CAN DISCRIMINATE IMMUNOGLOBULIN G4-RELATED SCLEROSING CHOLANGITIS AND PRIMARY SCLEROSING CHOLANGITIS
Conference paper
Selvaraj E. et al, (2021), GUT, 70, A2 - A3
https://orcid.org/0000-0001-8781-7459