Postdoctoral Research Assistant
My current research interests include the neurobiological basis of mood disorders, in particular depression and anxiety. I focus on the relationship between the gut microbiome and brain health, including the mediating role of the immune system. I have a special interest in metabolomics techniques, both as a mechanistic approach to understand gut-to-brain communication and as a tool for biomarker discovery for precision medicine.
A multivariate blood metabolite algorithm stably predicts risk and resilience to major depressive disorder in the general population.
Radford-Smith DE. et al, (2023), EBioMedicine, 93
HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation.
Radford-Smith DE. et al, (2023), Lipids Health Dis, 22
Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression
Radford-Smith DE. and Anthony DC., (2023), Nutrients, 15, 1880 - 1880
Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders
Radford-Smith DE. and Anthony DC., (2023), Metabolites, 13, 455 - 455
IFN-λ Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis.
Sebina I. et al, (2022), J Immunol