Growing evidence implicates a vital role for TPC2/Ca2+ signaling in pathophysiological processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer therapeutic target. In this issue of Cell Chemical Biology, Müller et al. (2021) develop TPC2 inhibitors, SG005 and SG-094, exhibiting anti-tumor effects with potential translational relevance.
10.1016/j.chembiol.2021.07.020
Journal article
2021-08-19T00:00:00+00:00
28
1103 - 1105
2
Calcium, Calcium Channels, Humans, Neoplasms, Signal Transduction