Colleges
Paolo Tammaro
Professor of Pharmacology
- Director of Graduate Studies
- Fellow & Tutor in Medicine & Biomedical Sciences, The Queen's College
- Visiting Professor at Nagoya City University in Japan
Key publications
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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Bushell SR. et al, (2019), Nat Commun, 10
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Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.
Rorsman NJG. et al, (2018), Br J Pharmacol, 175, 2028 - 2045
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Contrasting effects of phosphatidylinositol 4,5-bisphosphate on cloned TMEM16A and TMEM16B channels.
Ta CM. et al, (2017), Br J Pharmacol, 174, 2984 - 2999
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Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker.
Ta CM. et al, (2016), Br J Pharmacol, 173, 511 - 528
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Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.
Smith KJ. et al, (2013), Int J Cardiol, 168, 3506 - 3513
Recent publications
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Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function.
Al-Hosni R. et al, (2025), Br J Pharmacol
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The TMEM16A channel as a potential therapeutic target in vascular disease.
Al-Hosni R. et al, (2024), Curr Opin Nephrol Hypertens, 33, 161 - 169
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Identification of determinants of lipid and ion transport in TMEM16/anoctamin proteins through a Bayesian statistical analysis.
Moran O. and Tammaro P., (2024), Biophys Chem, 308
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The TMEM16A anion channel as a versatile regulator of vascular tone.
Tammaro P., (2023), Sci Signal, 16
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The pharmacology of the TMEM16A channel: therapeutic opportunities.
Al-Hosni R. et al, (2022), Trends Pharmacol Sci